INTRODUCTION

Common Name: Gibberellic acid 4% EC
Use: Plant growth regulator. Promote stem and leaves growth obviously, and seed germinating; make long day plnat flowers in short day condition; induce flower; prevent flower and fruit drop.
                                                                                 
Company Name: Penzeal Industry Co., Ltd.
Situation      : Asia
Nationality    : China
Address       : Rm.709 East Block Huatai Zonghe Building, No.76 Xinwen Road, Futian District, Shenzhen, P. R. China
Remarks      : Penzeal Industry Co., Ltd. is a specialized trade company in the field of import & export of agrochemical products. The company possesses very strong networks of relationships, complete techniques and staffing. In respect of products sources, we own a very professional team, whose members have been engaged in purchasing and operation of agrochemical products for more than 10 years. For more, we have established long-term and good co-operation relationship with most outstanding suppliers in China, so we are fully confident to offer products with good quality but low price to our esteemed customers. In terms of shipment, we have very perfect Import & Export service system, and have established good co-operation relationship with many shipping and air companies, so that we can chose the best shipping or air lines for your goods to different countries and areas, of course accordingly we offer a series of service including fast custom declaration and insurance.
                                                                                 
APPLICANT
Name         : Penzeal Industry Co., Ltd.
Address       : Rm.709 East Block Huatai Zonghe Building, No.76 Xinwen Road, Futian District, Shenzhen, P. R. China
Nationality     : China
Tel.           : 86-755-83881096
Authority cert.  : We are registered in the Ministry of Agriculture as an Established Company.
Indentity cert.  : We are registered in the Ministry of Agriculture as an Established Company.
Remarks       : Penzeal Industry Co., Ltd. is a specialized trade company in the field of import & export of agrochemical products. The company possesses very strong networks of relationships, complete techniques and staffing. In respect of products sources, we own a very professional team, whose members have been engaged in purchasing and operation of agrochemical products for more than 10 years. For more, we have established long-term and good co-operation relationship with most outstanding suppliers in China, so we are fully confident to offer products with good quality but low price to our esteemed customers. In terms of shipment, we have very perfect Import & Export service system, and have established good co-operation relationship with many shipping and air companies, so that we can chose the best shipping or air lines for your goods to different countries and areas, of course accordingly we offer a series of service including fast custom declaration and insurance.

Chemistry of The Product
SYNONYMS
Common Name: Gibberellic acid
Code Number: N/A
Trade Name: Alphagain 4% EC
                                                                                 
Initial Regist.: N/A
Chemical Class: Gibberellins
Local Synonyms: GA 3, Activol, Berelex
                                                                                 
Chemical Name: (1α,2β,4aα,4bβ,10β)-2-4a,7-trihydroxy-1-methyl-8-methylenegibb-3-ene-1,10-dicarboxylic aicd 1,4a-lactone
Source: Gibberellic acid
                                                                                    
Structural Formula:

                                                                                 
Physical and Chemical Properties:
Molecular Weight: 346.4
Physical Form: Crystal
Technical Purity: 90%
Vapour Pressure: N/A
Colour & Odour: White to slight yellow, odourless
Density: N/A
Solubility: In water 5g/l (20 oC). Soluble in methanol, ethanol, acetone, and aqueous alkalis; slightly soluble in diethyl ether and ethyl acetate. Insoluble in chloroform
Octanol Number : N/A

Type of Formulations And Specifications

SPECIFICATIONS OF FORMULATIONS
Appearance            : Colourless to slight yellow liquid
Alkalinity or Acidity     : N/A
Suspensibility           : N/A
Emulsification Properties : Qualified with FAO specification
Density                : 0.83±0.05
Viscosity               : N/A
Persistent foam                   : N/A
Flash Point             : N/A
Freeze Point            : N/A
Wettability             : N/A.
Particle Size            : N/A
Compatability          : Incompatible with strong acid or alkaline agrochemicals
Heat Stability          : Qualified in thermal stability at 54oC
Storage Stability        : Qualified in storage stability
Mixing Properties       : N/A
Methods of Analysis     : HPLC
Levels of Impurities     : N/A

Biological Spectrum
Pesticidal efficacy (list of pests):
Promote stem and leaves growth obviously, and seed germinating; make long day plnat flowers in short day condition; induce flower; prevent flower and fruit drop.
                                                                                     
Mode of action:
Acts as a plant growth regulator on account of its physiological and morphological effects in extremely low concentrations. Translocated. Generally affects only the plant parts above the soil surface.
                                                                                    
Use and Recommendations:

Phytotoxicity:
Phytotoxic to plant at high dosage..

Toxicological Studies
Acute Mammalian Toxicity:

Chronic Toxicity
Two subchronic oral toxicity studies for Gibberellic Acids were reviewed in connection with the RED process. In the first subchronic dietary study there was a NOEL of 10,000 ppm and a LOEL of 50,000 ppm based on the occurrence of soft stools in both sexes of rats and increased BUN levels, liver and kidney weights in females. In the second study, there was a NOEL of 10,000 ppm and a LOEL of 25,000 ppm based on alterations in clinical chemistry, decreased food consumption, decreased body weights, increases in relative organ weights (brain, kidney, testis) and gross histopathological changes in the kidney. 

Carcinogenicity (WHO-IARC)
No carcinogenicity.

Delayed neurotoxicity (WHO)
No neurotoxicity.

Hormonal disruption (WHO)
No effect on hormone.

Teratogenicity & Reproduction (WHO)
No teratogenicity or reproductive effect.

Mutagenicity (WHO)
Gibberellic Acid (GA3 ) Salmonella typhimurium test strains TA 98, TA 100, TA 1535, TA 1537, and TA 1538 at concentrations ranging from 0 to 10,000 ug/plate with negative test results up to limit dose of 5,000 and 10,000 ug/plate. The mutagenicity of Gibberellins (GA4+GA 7) was tested in an Ames assay with Salmonella typhimurium test strains TA 98, TA 100, TA 1535, TA 1537, and TA 1538 at concentrations ranging from 0 to 10,000 ug/plate. Test results were negative up to 10,000 ug/plate in the standard set of five histidine negative strains of Salmonella typhimurium LT2.

A mouse-micronucleus assay on Gibberellins (GA4 + GA 7) indicated that no increased incidence of micronucleated-polychromatic erythrocytes (m-PCE) were found at levels up to 1200 mg/kg.

An unscheduled DNA synthesis in rat hepatocytes conducted with Gibberellins technical 90% (GA4+GA7 ) was negative for induction of UDS up to 1260 ug/ml, the limit of solubility (MRID 40261603). A second unscheduled DNA synthesis in rat hepatocytes conducted with Gibberellins also was negative.

ECOTOXICOLOGY
1- Aquatic Organisms
LC50 (96 h) for rainbow trout > 150ppm

2- Earthworms
Acute 14d-LC50 > 1250 mg/kg soil

3-Honey bees
Acute contact toxicity, 48h-LC50 > 25μg a.s./bee

4- Birds
Acute oral LD50 for bobwhite quail > 2500 mg/kg, acute oral LD50 > 4640 mg/kg.

5- Parasites and Predators
No toxicity to parasites or predators.

ENVIRONMENTAL CHEMISTRY

Fate in Soil:
Gibberellic acid is not persistent in soil, DT50 4 d.

Effect on microbial Process:
No effect on microorganisms.

Method of Res.Analysis: HPLC
                                                                                  

Fate in Plant:
Absorbed and translocated by plant, generally affects only the plant parts above the soil surface.

Fate in Water:
Slowly undergoes hydrolysis in aqueous or aqueous-alcoholic solutions, DT50(20oC)c.14d (3-4), 14 d (pH 7).

Photo degradation Rate:
No data available.

Rate of hydrolysis at PH levels :
DT50(20oC)c.14d (3-4), 14 d (pH 7)

Methods of analysis: HPLC
                                                                                    
Fate in Animal:
Rapidly eliminate via faece and urine.

SAFETY HANDLING STORAGE AND DISPOSAL

Storage:
Requirements for storage areas and containers
Keep out of the reach of children.
Advice on common storage
Keep away from food, drink and animal feedingstuffs.
Suitable materials
Rigid material with protection against moisture.

                                                                                 
Shelf Life:
2 years.

                                                                                  
Handling Precautions:
Do not breathe dust. Avoid contact with eyes, skin, or clothing. Wash thoroughly after handling. Wash clothing after use. Do not store or consume food, drink, or tobacco in areas where they may become contaminated with this material.
                                                                                 
Containers (Lining):
50 ml, 100 ml, 200 ml, 500 ml, 1L, bottle. Or other packing according to requirement.

                                                                                  
Signs and symptoms of Over Exposure:
Dizziness, headache, nausea, abdomen convulsion, vomit, hidrosis, myosis, weep, spit hypersecretion, can cause lethal danger if contact or inhale to much directly.

                                                                                  
Note to Physician:
No special advice. Treat symptomatically.

                                                                                 
FIRST AID:
IF Swallowed:
If the victim is convulsing or unconscious, administer a glass of water, ensure that the victim's airway is open and if symptoms developed, call a physician immediately..
If in eyes: 
Hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.
If on skin or clothing: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for treatment advice.
IF Inhaled
If person is not breathing, call an ambulance, then give artificial respiration, preferably mouth-to-mouth if possible. Call a poison control center or doctor for further treatment advice. Take affected person to fresh air.
                                                                                 
ANTIDOTE:
No special antidote.
Administer glasses of water if swallow.

                                                                                  
REMARKS:
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchant ability or any other warranty, express or implied, with respect to such information, we assumes no legal responsibility for use or reliance upon these data. The date on this sheet relates only to the specific material designated herein, and users should make their own investigations to determine the suitability of the information for their particular purposes.